6bom

Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.

Structural highlights

6bom is a 6 chain structure with sequence from Aspfc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	mcsA, AFUB_094700 (ASPFC)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PRPC_ASPFC] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. Plays a key role in the estabishment of invasive pulmonary aspergillosis.^[1]

References

↑ Ibrahim-Granet O, Dubourdeau M, Latge JP, Ave P, Huerre M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol. 2008 Jan;10(1):134-48. doi: 10.1111/j.1462-5822.2007.1025.x. PMID:17973657 doi:http://dx.doi.org/10.1111/j.1462-5822.2007.1025.x

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OCA

[1] Ibrahim-Granet O, Dubourdeau M, Latge JP, Ave P, Huerre M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol. 2008 Jan;10(1):134-48. doi: 10.1111/j.1462-5822.2007.1025.x. PMID:17973657 doi:http://dx.doi.org/10.1111/j.1462-5822.2007.1025.x

[1]

6bom

Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.

Structural highlights

Function

References

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6bom

Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.

Structural highlights

Function

References

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