6b75

Crystal Structure of human NAMPT in complex with NVP-LOQ594Crystal Structure of human NAMPT in complex with NVP-LOQ594

Structural highlights

6b75 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	6atb, 6azj
Activity:	Nicotinamide phosphoribosyltransferase, with EC number 2.4.2.12
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

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OCA