Tumor necrosis factor

Function Tumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNFβ is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase). Relevance TNF is studied as both a target and a therapeutic in malignant diseases. Structural highlights The biological assembly of human tumor necrosis factor is (PDB entry 2az5). .

spinqualitylabelsall models Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of tumor necrosis factor3D Structures of tumor necrosis factor

Updated on 28-September-2018

{"openlevels":0}

• TNF α
  • 1tnf – hTNF – human
    
  • 2tun, 1a8m, 4tsv, 5tsw, 2e7e, 2zjc, 2zpx, 5tsw, 5uui – hTNF (mutant)
    
  • 2tnf – TNF – mouse
    
  • 2az5, 5mu8 – hTNF + inhibitor
    
  • 3it8 – hTNF + poxvirus 2L protein
    
  • 3l9j – hTNF + antagonist
    
  • 3alq – hTNF (mutant) + TNF receptor
    
  • 4g3y, 3wd5 – hTNF + antibody
    
  • 4twt – hTNF + peptide
    
• TNF β
  • 1tnr – hTNF + TNF receptor p55
    
• TNF
  • 2vfj – hTNF ovarian tumor domain
    
  • 5m2i, 5m2j, 5m2m, 5wux, 5yoy – hTNF + antibody