6f2r

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A hetrotetramer of human HspB2 and HspB3A hetrotetramer of human HspB2 and HspB3

Structural highlights

6f2r is a 21 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[HSPB3_HUMAN] Distal hereditary motor neuropathy type 2. The disease is caused by mutations affecting the gene represented in this entry.

Function

[HSPB2_HUMAN] May regulate the kinase DMPK.[1] [HSPB3_HUMAN] Inhibitor of actin polymerization.

References

  1. Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. J Cell Biol. 1998 Mar 9;140(5):1113-24. PMID:9490724

6f2r, resolution 3.90Å

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OCA