5z8l

crystal structure of Arabidopsis thaliana EBS in complex with an H3K27me3 peptidecrystal structure of Arabidopsis thaliana EBS in complex with an H3K27me3 peptide

Structural highlights

5z8l is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[EBS_ARATH] Chromatin remodeling factor that binds to methylated histone (e.g. H3K4me2/3) to prevent their acetylation (e.g. H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulating the transcription of target genes (PubMed:25281686). Negative regulator in developmental processes in a gibberellic acid- (GA-) dependent manner, such as germination, flowering induction, and flower organ specification, probably by modulating developmental gene expression (PubMed:11340178, PubMed:25281686). Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering (PubMed:25281686). Negatively regulates the expression of the floral integrator FT epigenetically, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation at FT locus (PubMed:25281686, PubMed:12837946).^[1] ^[2] ^[3]

References

↑ Gomez-Mena C, Pineiro M, Franco-Zorrilla JM, Salinas J, Coupland G, Martinez-Zapater JM. early bolting in short days: an Arabidopsis mutation that causes early flowering and partially suppresses the floral phenotype of leafy. Plant Cell. 2001 May;13(5):1011-24. PMID:11340178
↑ Pineiro M, Gomez-Mena C, Schaffer R, Martinez-Zapater JM, Coupland G. EARLY BOLTING IN SHORT DAYS is related to chromatin remodeling factors and regulates flowering in Arabidopsis by repressing FT. Plant Cell. 2003 Jul;15(7):1552-62. PMID:12837946
↑ Lopez-Gonzalez L, Mouriz A, Narro-Diego L, Bustos R, Martinez-Zapater JM, Jarillo JA, Pineiro M. Chromatin-dependent repression of the Arabidopsis floral integrator genes involves plant specific PHD-containing proteins. Plant Cell. 2014 Oct;26(10):3922-38. doi: 10.1105/tpc.114.130781. Epub 2014 Oct, 3. PMID:25281686 doi:http://dx.doi.org/10.1105/tpc.114.130781

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OCA

[1] Gomez-Mena C, Pineiro M, Franco-Zorrilla JM, Salinas J, Coupland G, Martinez-Zapater JM. early bolting in short days: an Arabidopsis mutation that causes early flowering and partially suppresses the floral phenotype of leafy. Plant Cell. 2001 May;13(5):1011-24. PMID:11340178

[2] Pineiro M, Gomez-Mena C, Schaffer R, Martinez-Zapater JM, Coupland G. EARLY BOLTING IN SHORT DAYS is related to chromatin remodeling factors and regulates flowering in Arabidopsis by repressing FT. Plant Cell. 2003 Jul;15(7):1552-62. PMID:12837946

[3] Lopez-Gonzalez L, Mouriz A, Narro-Diego L, Bustos R, Martinez-Zapater JM, Jarillo JA, Pineiro M. Chromatin-dependent repression of the Arabidopsis floral integrator genes involves plant specific PHD-containing proteins. Plant Cell. 2014 Oct;26(10):3922-38. doi: 10.1105/tpc.114.130781. Epub 2014 Oct, 3. PMID:25281686 doi:http://dx.doi.org/10.1105/tpc.114.130781

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