5o6p

Structure of beta-phosphoglucomutase D10N mutant in complex with glucose-1,6-bisphosphateStructure of beta-phosphoglucomutase D10N mutant in complex with glucose-1,6-bisphosphate

Structural highlights

5o6p is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Activity:	Beta-phosphoglucomutase, with EC number 5.4.2.6
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PGMB_LACLA] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.^[1] ^[2]

References

↑ Qian N, Stanley GA, Bunte A, Radstrom P. Product formation and phosphoglucomutase activities in Lactococcus lactis: cloning and characterization of a novel phosphoglucomutase gene. Microbiology. 1997 Mar;143 ( Pt 3):855-65. PMID:9084169
↑ Lahiri SD, Zhang G, Dai J, Dunaway-Mariano D, Allen KN. Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry. 2004 Mar 16;43(10):2812-20. PMID:15005616 doi:10.1021/bi0356810

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OCA

[1] Qian N, Stanley GA, Bunte A, Radstrom P. Product formation and phosphoglucomutase activities in Lactococcus lactis: cloning and characterization of a novel phosphoglucomutase gene. Microbiology. 1997 Mar;143 ( Pt 3):855-65. PMID:9084169

[2] Lahiri SD, Zhang G, Dai J, Dunaway-Mariano D, Allen KN. Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry. 2004 Mar 16;43(10):2812-20. PMID:15005616 doi:10.1021/bi0356810

[1]

[2]

5o6p

Structure of beta-phosphoglucomutase D10N mutant in complex with glucose-1,6-bisphosphateStructure of beta-phosphoglucomutase D10N mutant in complex with glucose-1,6-bisphosphate

Structural highlights

Function

References

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5o6p

Structure of beta-phosphoglucomutase D10N mutant in complex with glucose-1,6-bisphosphateStructure of beta-phosphoglucomutase D10N mutant in complex with glucose-1,6-bisphosphate

Structural highlights

Function

References

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