Glycoprotein GP

Function The virus contains a surface glycoprotein PG that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of GP1 and GP2 . Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion. For details see GP1 of Lassa Virus.

spinqualitylabelsall models Ebolavirus glycosylated GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code 3s88) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of glycoprotein GP3D Structures of glycoprotein GP

Updated on 04-June-2018

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• Glycoprotein GP
  • 2wfo – MvGP1 – Machupo virus
    
  • 4zjf – GP1 – Lassa virus
    
  • 5nff – GP1 – Morogoro virus
    
  • 5nsj – GP1 – Whitewater arroyo mammarenavirus
    
  • 3lj5, 4v4k – GP1 – Bacteriophage p22
    
  • 4n21, 4n23 – GP2 ectodomain – CAS virus
    
• Glycoprotein GP complex
  • 3ve0, 3s88 – GP1 + GP2 + antibody – Sudan ebolavirus
    
  • 5f1b – ZevGP1 + GP2 + Niemann-Pick C1 protein – Zaire ebolavirus
    
  • 6f5u, 6f6i, 6f6n, 6f6s – ZevGP1 + GP2 + antidepressant
    
  • 3csy, 5kel, 5ken – ZevGP1 + GP2 + antibody
    
  • 5uqy – GP1 + GP2 + antibody – Marburg virus
    
  • 3kas – MvGP1 + transferrin receptor 1
    
  • 5nuz – GP1 + antibody – Junin virus