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Purine-rich element binding protein alphaPurine-rich element binding protein alpha

Introduction Purine-rich element binding protein alpha (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to bind sequence-specific purine-rich regions of ssDNA and ssRNA, specifically GGN repeats. Purα is a member of the PUR family of proteins, which includes Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) encoded by the Acta2 gene. It is also known to be involved in DNA replication and cell cycle regulation as well as mRNA translation. It plays a crucial role in nervous system development, and mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section). Structure facilitates dimerization of Purα monomers. The association of two repeat III domains forms what is termed the "intermolecular domain". A PUR domain is analogous to a left-handed handshake. PUR repeat I-II represented from 5fgp. Function functions as a homodimer or heterodimer with PurB (and PurG?), PurA is known to repress various genes including , Y57 (repeat I) and F145 (repeat II) have been implicated in the DNA unwinding activity of PurA. Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. You may include any references to papers as in: the use of JSmol in Proteopedia

spinqualitylabelsall models PDB ID 5fgp Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

FunctionFunction

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spinqualitylabelsall models scene='78/786627/5fgp_57and145/1' Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image