Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNASolution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA
Structural highlights
1vdl is a 1 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
[UBP25_MOUSE] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity).[1] The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.[2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Bosch-Comas A, Lindsten K, Gonzalez-Duarte R, Masucci MG, Marfany G. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. Cell Mol Life Sci. 2006 Mar;63(6):723-34. PMID:16501887 doi:http://dx.doi.org/10.1007/s00018-005-5533-1
↑Bosch-Comas A, Lindsten K, Gonzalez-Duarte R, Masucci MG, Marfany G. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. Cell Mol Life Sci. 2006 Mar;63(6):723-34. PMID:16501887 doi:http://dx.doi.org/10.1007/s00018-005-5533-1
