6bgg

Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptideSolution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide

Structural highlights

6bgg is a 2 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

Function

[BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.^[1]

References

↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

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OCA

[1] LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

[1]

6bgg

Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptideSolution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide

Structural highlights

Disease

Function

References

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6bgg

Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptideSolution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide

Structural highlights

Disease

Function

References

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