6bgo

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Singly PafE-capped 20S CP in Mycobacterium tuberculosisSingly PafE-capped 20S CP in Mycobacterium tuberculosis

Structural highlights

6bgo is a 35 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Proteasome endopeptidase complex, with EC number 3.4.25.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PSA_MYCTA] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [BPA_MYCTO] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.[UniProtKB:P9WKX3] [PSB_MYCTA] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

6bgo, resolution 4.20Å

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