Ectonucleotide pyrophosphatase/phosphodiesterase

Function Ectonucleotide pyrophosphatase/phosphodiesterase family of proteins mediates purinergic signaling by degrading extracellular nucleotides and also participate in phospholipid metabolism Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) converts extracellular nucleotides into inorganic pyrophosphate. It regulates osteoblast differentiation Ectonucleotide pyrophosphatase/phosphodiesterase 2 or autotoxin (ENPP2) hydrolyzes lysophospholipids . Ectonucleotide pyrophosphatase/phosphodiesterase 4 or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation Ectonucleotide pyrophosphatase/phosphodiesterase 6 (ENPP6) hydrolyzes choline-containing compounds like lysophosphatidylcholine Ectonucleotide pyrophosphatase/phosphodiesterase 7 or alkaline sphingomyelinase (ENPP7) converts sphingomyelin into ceramide and phosphocholine Relevance EPPN7 may protect the intestinal mucosa from inflammation and tumorigenesis. Structural highlights The active site of ENPP1 contains and the reaction product AMP.

spinqualitylabelsall models Mouse glycosylated Se-Met ENPP1 complex with AMP and Ca+2 (green) and Zn+2 ions (grey) (PDB code 4gtw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase

Updated on 07-February-2018

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• ENPP1
  • 4b56 – mENPP1 – mouse
    
  • 2ys0 – hENPP1 somatomedin domain – human - NMR
    
  • 4gtw, 4gtx, 4gty, 4gtz – mENPP1 (mutant) + nucleotide
    
• ENPP2 (Autotoxin)
  • 5ijq, 5ijs – rENPP2 - rat
    
  • 2xr9 – rENPP2 (mutant)
    
  • 5l0b, 5l0e, 5l0k – rENPP2 + inhibitor
    
  • 5lqq, 5m0d, 2xrg, 5m0e, 5m0m, 5m0s – rENPP2 (mutant) + inhibitor
    
  • 5dlt, 5dlw, 5dlv – rENPP2 (mutant) + steroid
    
  • 3nkm, 5inh – mENPP2
    
  • 3nkn, 3nko, 3nkp, 3nkq, 3nkr – mENPP2 + lipid
    
  • 5hrt – mENPP2 + DNA
    
  • 3wav, 3waw, 3wax, 3way, 5lia – mENPP2 + inhibitor
    
  • 4zg6, 4zg7, 4zg9, 4zga, 5kxa, 5m7m, 5mhp – hENPP2 (mutant) + inhibitor
    
• ENPP4
  • 4lr2 – hENPP4
    
  • 4lqy – hENPP4 + AMP
    
• ENPP5
  • 5vem, 5ven – hENPP5
    
  • 5veo – mENPP5 (mutant) + AMP
    
• ENPP6
  • 5ege – mENPP6 (mutant)
    
  • 5egh – mENPP6 (mutant) + phosphocholine
    
• ENPP7 (Alkaline sphingomyelinase)
  • 5udy – hENPP7
    
  • 5tcd – hENPP7 + phosphocholine