5wbj

Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1

Structural highlights

5wbj is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RTOR1_ARATH] Probable component of the plant TOR kinase pathway that recruits substrates for TOR. Modulates plant cell growth and regulates the activity of ATPK1 kinase in response to osmotic stress.^[1] [4EBP1_HUMAN] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.^[2]

References

↑ Mahfouz MM, Kim S, Delauney AJ, Verma DP. Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals. Plant Cell. 2006 Feb;18(2):477-90. doi: 10.1105/tpc.105.035931. Epub 2005 Dec 23. PMID:16377759 doi:http://dx.doi.org/10.1105/tpc.105.035931
↑ Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 1994 Oct 27;371(6500):762-7. PMID:7935836 doi:http://dx.doi.org/10.1038/371762a0

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OCA

[1] Mahfouz MM, Kim S, Delauney AJ, Verma DP. Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals. Plant Cell. 2006 Feb;18(2):477-90. doi: 10.1105/tpc.105.035931. Epub 2005 Dec 23. PMID:16377759 doi:http://dx.doi.org/10.1105/tpc.105.035931

[2] Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 1994 Oct 27;371(6500):762-7. PMID:7935836 doi:http://dx.doi.org/10.1038/371762a0

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5wbj

Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1

Structural highlights

Function

References

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5wbj

Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1

Structural highlights

Function

References

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