Nitrophorin

Function Nitrophorins (NP) are NO transport heme-containing proteins from the saliva of blood-feeding insects which act as vasodilators and anti-platelet agents. The NO is bound to the ferric form of NP with Kds in the micromolar or nanomolar range. Thus upon injection of the saliva into the tissue of the victim, the NO ca dissociate to cause vasodilation and inhibition of platelet aggregation. Structural highlights The NPs structures contain a large component of β-sheet structure which is unusual for heme-containing proteins. The NO molecule is bound to the ferric heme opposite the His and Glu residues interacting with it.

spinqualitylabelsall models Heme-containing nitrophorin 7 complex with NO and glycerol (PDB code 4xme) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of deaminase3D Structures of deaminase

Updated on 19-December-2017

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• Salivary nitrophorin (Cimex nitrophorin)
  • 1ntf, 2imq – bbNP – bed bug
    
  • 4l1y, 4l1z – bbNP (mutant)
    
  • 1y21, 1yjh – bbNP + NO
    
  • 4l20, 4l21 – bbNP (mutant) + NO
    
  • 1si6 – bbNP + CO
    
  • 1np1 – bbNP + histamine
    
• Nitrophorin 1
  • 2np1 – RpNP1 – Rhodnius prolixus
    
  • 4np1 – RpNP1 + NO
    
  • 3np1 – RpNP1 + CN
    
  • 1u18 – RpNP1 (mutant) + histamine
    
  • 1u17 – RpNP1 (mutant) + imidazole
    
• Nitrophorin 2 (Prolixin-S)
  • 1euo, 2a3f, 2acp, 2ah7, 2al0 – RpNP2
    
  • 2all, 2amm – RpNP2 (mutant)
    
  • 1t68 – RpNP2 + NO
    
  • 2hys – RpNP2 + CN
    
  • 1pee – RpNP2 + imidazole
    
  • 1pm1, 2asn – RpNP2 (mutant) + imidazole
    
  • 2gtf – RpNP2 + pyrimidine
    
  • 2eu7 – RpNP2 (mutant) + NH3
    
• Nitrophorin 4
  • 1np4, 1d2u, 1d3s, 1u0x, 2ofm, 1x8q, 1ywd, 2at6 – RpNP4
    
  • 3fll, 1sxy, 1sy0, 1sy2, 3tga – RpNP4 (mutant)
    
  • 1erx, 1koi, 1x8n, 1x8o, 1ywb, 2at5, 2at8 – RpNP4 + NO
    
  • 4grj, 1sy1, 1sxw, 1sxx, 1sy3, 2at0, 2ofr – RpNP4 (mutant) + NO
    
  • 3mvf – RpNP4 + NO2
    
  • 5hwz, 3tgc – RpNP4 (mutant) + NO2
    
  • 1eqd – RpNP4 + CN
    
  • 1ywa, 1ywc – RpNP4 + CO
    
  • 1ml7 – RpNP4 + iodopyrazole
    
  • 1ikj – RpNP4 + imidazole
    
  • 1sxu, 2at3, 3tgb – RpNP4 (mutant) + imidazole
    
  • 1x8p, 3c77, 3c78 – RpNP4 + NH3
    
  • 4gnw, 3c76 – RpNP4 (mutant) + NH3
    
  • 1ike – RpNP4 + histamine
    
  • 4hpa – RpNP4 + H2S
    
  • 4hpb – RpNP4 + mercaptoethaol
    
  • 4hpc – RpNP4 + cysteine
    
  • 4hpd – RpNP4 + homocysteine
    
• Nitrophorin 7
  • 4xmc, 4xmd – RpNP7
    
  • 4xme – RpNP7 + NO
    
  • 4xmf – RpNP7 + histamine
    
  • 4xmg – RpNP7 + imidazole
    
  • 4xmh – RpNP7 + tripeptide