5wt3

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Pyrococcus abyssi methyltransferase PaTrm5a bound by MTA and cognate tRNAPyrococcus abyssi methyltransferase PaTrm5a bound by MTA and cognate tRNA

Structural highlights

5wt3 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:tRNA (guanine(37)-N(1))-methyltransferase, with EC number 2.1.1.228
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TRM5A_PYRAB] Specifically methylates the N1 position of guanosine-37 in tRNA(Phe). In vitro, can also methylate the C7 position of 4-demethylwyosine (imG-14).[1]

References

  1. ↑ de Crecy-Lagard V, Brochier-Armanet C, Urbonavicius J, Fernandez B, Phillips G, Lyons B, Noma A, Alvarez S, Droogmans L, Armengaud J, Grosjean H. Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea. Mol Biol Evol. 2010 Sep;27(9):2062-77. doi: 10.1093/molbev/msq096. Epub 2010 Apr , 9. PMID:20382657 doi:http://dx.doi.org/10.1093/molbev/msq096

5wt3, resolution 3.20Å

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