Circadian clock protein

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Circadian clock proteins measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA[1] stimulates KaiC[2] which adds phosphate groups to itself. Then KaiC binds to KaiB[3] which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.[4] For details of KaiC see Circadian Clock Protein KaiC.

Circadian clock protein KaiA from Synechococcus elongatus is (PDB entry 1r8j).

Circadian clock protein KaiA (PDB entry 1r8j)

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3D Structures of circadian clock protein3D Structures of circadian clock protein

Updated on 26-November-2017

ReferencesReferences

  1. Ye S, Vakonakis I, Ioerger TR, LiWang AC, Sacchettini JC. Crystal structure of circadian clock protein KaiA from Synechococcus elongatus. J Biol Chem. 2004 May 7;279(19):20511-8. Epub 2004 Mar 8. PMID:15007067 doi:10.1074/jbc.M400077200
  2. Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M. Visualizing a circadian clock protein: crystal structure of KaiC and functional insights. Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218 doi:10.1016/j.molcel.2004.07.013
  3. . PMID:15716247
  4. Harmer SL, Panda S, Kay SA. Molecular bases of circadian rhythms. Annu Rev Cell Dev Biol. 2001;17:215-53. PMID:11687489 doi:http://dx.doi.org/10.1146/annurev.cellbio.17.1.215

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Michal Harel, Alexander Berchansky, Joel L. Sussman