3n0t

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Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826AHuman dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A

Structural highlights

3n0t is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:DPP2, DPP7, QPP (HUMAN)
Activity:Dipeptidyl-peptidase II, with EC number 3.4.14.2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DPP2_HUMAN] Plays an important role in the degradation of some oligopeptides.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Maes MB, Lambeir AM, Gilany K, Senten K, Van der Veken P, Leiting B, Augustyns K, Scharpe S, De Meester I. Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). Biochem J. 2005 Mar 1;386(Pt 2):315-24. PMID:15487984 doi:http://dx.doi.org/10.1042/BJ20041156

3n0t, resolution 2.45Å

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OCA
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