Ribosome inactivating protein

Function Ribosome inactivating protein (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA. Type 1 RIP have a single chain, while type 2 RIP (i.e., ricin, ebulin and nigrin) have two chains. Momorcharin is a RIP isolated from several plants. Relevance RIP is being investigated as an immunotoxin for cancer treatment. Besides the anti-tumor activity of RIP, it was shown to have antiviral, antifungal, insecticidal, ribonuclease and deoxyribonuclease activities. Enhanced expression of RIP in plants confers an increased resistance to virus, fungi, insects, drought and salinity. α-momorcharin has potent inhibitory effect on some cancer cells. Structural highlights The . Water molecules shown as red spheres.

spinqualitylabelsall models Ribosome inactivating protein from pokeweed complex with adenine (PDB code 1qci) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ribosome inactivating protein3D Structures of ribosome inactivating protein

Updated on 25-October-2017

{"openlevels":0}

• Pokeweed ribosome inactivating protein
  • 1apa, 1paf, 1pag, 1qcg – apRIP – american pokeweed
    
  • 1j1q, 1gik – apRIP-S
    
  • 1j1r – apRIP-S + adenine
    
  • 1j1s – apRIP-S + formycin
    
  • 1qci – apRIP + adenine
    
  • 1d6a – apRIP + guanine
    
  • 1qcj – apRIP + pteoric acid
    
  • 1lln – apRIP-3 + methylated lysine
    
• Dianthin 30 ribosome inactivating protein
  • 1lp8, 1rl0 – cpRIP – clove pink
    
  • 1lpc – cpRIP + cAMP
    
  • 1lpd – cpRIP + adenine
    
• Type 1 ribosome inactivating protein
  • 2g5x – RIP – scarlet lychnis
    
  • 3ctk – RIP – bougainvillea
    
  • 3mrw, 3s9q, 4kmk, 4kwn, 4l66, 1cf5, 5gmv, 4rzj – bgRIP – bitter gourd
    
  • 1f8q, 1aha, 1ahb, 1ahc, 1mri – bpα-RIP – balsam pear
    
• Type 1 ribosome inactivating protein complex with nucleotide
  • 3mry – bgRIP + aminopurine
    
  • 4kpv, 5y48 – bgRIP + pyrimidine derivative
    
  • 3rl9, 3u6z, 3u70, 3v2k – bgRIP + adenine
    
  • 4dwm, 4rzj – bgRIP + NAG
    
  • 3n1n, 3my6 – baRIP + guanine – balsam apple
    
  • 4f9n, 4i47 – bgRIP + guanine
    
  • 5ilx, 4o0o – bgRIP + uracil derivative
    
  • 5cso, 5cst – bgRIP + cytidine
    
  • 4kjh – bgRIP + cytosine
    
  • 4zt8 – bgα-RIP + pyrimidine derivative + cytosine
    
  • 4zu0, 4zz6, 4z44, 4o4q, 4o8e, 4q9f, 1mrg, 3q4p, 3qji, 4emf, 4emr, 5cso, 5cst, 5ilw, 5ilx – bgα-RIP + nucleotide
    
• Type 1 ribosome inactivating protein complex with peptide
  • 4fxa, 4lt4, 4m5a – bgRIP + arginine derivative
    
  • 3n3x – baRIP + polypeptide
    
  • 3n2d – bgRIP + polypeptide
    
• Type 1 ribosome inactivating protein other complexes
  • 3n31, 3n5d, 3n31, 3nfm, 3njs, 3nx9, 3n1d – baRIP + sugar
    
  • 3v14, 4fz9, 4guw, 4hoa, 5wv1 – bgRIP + sugar
    
  • 4lro – bgRIP + spermidine
    
  • 3sj6 – bgRIP + oxalane derivative
    
  • 3u6t – bgRIP + kanamycin
    
  • 3u8f – bgRIP + mycolic acid
    
  • 4h0z – bgRIP + acetyl-muramic acid
    
  • 4jtp – bgRIP + ascorbic acid
    
  • 4k2z – bgRIP + methylethylamine
    
  • 5cix – bgRIP + triethanolamine
    
  • 5gz7 – bgRIP + PEG
    
  • 4k2z – bgRIP + ethanediol
    
  • 4jtb – bgRIP + phosphate
    
  • 4lwx – bgRIP + peptidoglycan
    
  • 4yp2 – bgRIP + nicotinamide
    
  • 1mrh – bpα-RIP + formycin
    
  • 4fz9, 4xy7 – bgα-RIP + disaccharide
    
  • 4zt8 – bgα-RIP + pyrimidine derivative + cytosine
    
  • 5cf9 – bgα-RIP + NADP