MAP kinase phosphatase

Function

MAP kinase phosphatase (MKP) or Dual specificity phosphatase (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues^[1].

MKP-4 and MKP-5 are localized in the nucleus and cytosole
MKP-6, MKP-7 and MKP-3 are localized in the nucleus

Relevance

DUSP is implicated in the initiation and development of cancer^[2].

3D Structures of MAP kinase phosphatase3D Structures of MAP kinase phosphatase

3ezz – hMKP-2 (mutant) or DUSP-HVH2 - human
2fys - hMKP-3 peptide or DUSP-5 +rMAP kinase – rat
1hzm - hMKP-3 or DUSP-5
1mkp - hMKP-3 or DUSP-5 (mutant)
3lj8 – hMKP-4
2ouc, 2oud, 1zzw - hMKP-5 or DUSP-10
2wgp – hMKP-6 or DUSP-14
2vsw - hMKP-7 or DUSP-16
1j4x – hDUSP-3 (mutant)+peptide
2g6z – hDUSP-5
2rf6, 2q05 – DUSP – Vaccinia virus

ReferencesReferences

↑ Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106. PMID:18922965 doi:http://dx.doi.org/10.1124/pr.107.00106
↑ Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008 Jun;27(2):253-61. doi: 10.1007/s10555-008-9123-1. PMID:18330678 doi:http://dx.doi.org/10.1007/s10555-008-9123-1

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106. PMID:18922965 doi:http://dx.doi.org/10.1124/pr.107.00106

[2] Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008 Jun;27(2):253-61. doi: 10.1007/s10555-008-9123-1. PMID:18330678 doi:http://dx.doi.org/10.1007/s10555-008-9123-1

[1]

[2]