Folylpolyglutamate synthase

Function Folypolyglutamate synthase (FPGS) is active in intracellular folate homeostasis. Polyglutamated folates are substrates for generation of the primary metyhl group donor S-adenosylmethionine (SAM). Disease Mutations in FPGS are associated with increased childhood acute lymphoblastic leukemia. Relevance FPGS status is a predictor of chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate based chemotherapy and FPGS gene transfer may increase the sensitivity of colon cancer cells to 5-FU-based chemotherapy. Structural highlights The nucleotide-binding pocket of FPGS occupies a of the protein and . Water molecules shown as red spheres.

spinqualitylabelsall models Folypolyglutamate synthase complex with AMPPCP and Co+2 ion (pink) (PDB code 2vor) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of folypolyglutamate synthase3D structures of folypolyglutamate synthase

Updated on 20-October-2017

{"openlevels":0}

• Folypolyglutamate synthase
  • 3nrs – YpFPGS/dihydrofolate synthase – Yersinia pestis
    
  • 1o5z – FPGS – Thermotoga maritima
    
  • 2gca – LcFPGS – Lactobacillus casei
    
• Folypolyglutamate synthase complex
  • 3qcz – YpFPGS/dihydrofolate synthase + AMPPNP + Mn + glutamate
    
  • 3pyz – YpFPGS/dihydrofolate synthase + AMPPNP + Mn
    
  • 3n2a – YpFPGS/dihydrofolate synthase + ADP + Mg
    
  • 2vor – MtFPGS + ADP + AMPPNP – Mycobacterium tuberculosis
    
  • 2vos – MtFPGS + ADP
    
  • 2gc5, 2gc6, 2gcb – FPGS (mutant)
    
  • 1w78 – EcFPGS + ADP + DHPP – Escherichia coli
    
  • 1w7k – EcFPGS + ADP
    
  • 1jbv – LcFPGS + AMPPCP
    
  • 1jbw – LcFPGS + AMPPCP + folate derivative
    
  • 1fgs – LcFPGS + pyrophosphate