Insulin-like growth factor receptor

Insulin-like growth factor receptors (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. Memory-Enhancement by Traditional Chinese Medicine? Cognitive impairment is an emerging issue and increasing research points to the significant role of insulin-like growth factor I (IGF-I) in cognitive brain functions. (IGF-IR, PDB ID: 3i81, colored in darkmagenta) activation is critical for IGF-I to elicit desirable cognitive functions. Traditional Chinese medicine (TCM) ligands (orgin: Isatisin digotica, colored in green), (origin: Lindera aggregate, colored in deeppink), and (origin: Nelumbonucifera Gaertn, colored in salmon) showed high binding affinity towards IGF-IR at the binding site defined by the control in PDB ID: 3i81. Molecular dynamics simulation revealed that the TCM ligands were secured at the opening of the IGF-IR binding site for the duration of the MD. was stabilized by , was stabilized by , and was stabilized by (key residues are colored in yellow). Four different quantitative-structure activity relationship models consistently predicted bioactivity of the TCM ligands towards IGF-IR. In summary, the TCM candidates exhibit drug-like potential in both structural-based and ligand-based properties and may have potential for further applications in enhancing cognition.

spinqualitylabelsall models Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code 3i81) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of insulin-like growth factor receptor3D structures of insulin-like growth factor receptor

Updated on 20-October-2017

{"openlevels":0}

• IGFR I
  • 1igr – hIGFR I domains 1-3 – human
    
  • 1jqh, 1p4o - hIGFR I kinase domain (mutant)
    
  • 1m7n - hIGFR I kinase domain
    
  • 1k3a - hIGFR I kinase domain + insulin receptor substrate peptide
    
  • 2oj9, 2zm3, 3d94, 3f5p, 3i81, 3lvp, 3nw5, 3nw6, 3nw7, 3lw0, 3qqu, 3o23, 4d2r, 5fxq, 5fxr, 5fxs, 5hzn - hIGFR I kinase domain + inhibitor
    
• IGFR II
  • 1gqb - hIGFR II
    
  • 2kva - hIGFR II domain 5 – NMR
    
  • 2cnj - hIGFR II domain 11 - NMR
    
  • 2l2a, 2m68, 2m6t - hIGFR II domains 11 (mutant) - NMR
    
  • 2kvb - hIGFR II domain 5 + inhibitor – NMR
    
  • 2v5n - hIGFR II domains 11-12
    
  • 2v5o - hIGFR II domains 11-14
    
  • 2v5p - hIGFR II domains 11-13 + IGF II
    
  • 2l29 - hIGFR II domain 11 + IGF II - NMR
    
  • 1gp0, 1gp3, 1e6f - hIGFR II IGF II-binding domain
    
  • 1q25 - bIGFR II domains 1-3 – bovine
    
  • 1syo, 1sz0 - bIGFR II domains 1-3 + mannose-6-phosphate
    
  • 2lla - IGFR II domain 11 – short-beaked echidna - NMR