1w0y
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , , , | ||||||
| Activity: | Coagulation factor VIIa, with EC number 3.4.21.21 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TF7A_3771 COMPLEX
OverviewOverview
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
About this StructureAbout this Structure
1W0Y is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
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OCA- Pages with broken file links
- Coagulation factor VIIa
- Homo sapiens
- Protein complex
- Ackermann, J.
- Arcy, A D.
- Banner, D W.
- Groebke-Zbinden, K.
- Ji, Y H.
- Kirchhofer, D.
- Tschopp, T B.
- Wallbaum, S.
- Weber, L.
- Blood coagulation
- Calcium-binding
- Co-factor
- Coagulation
- Enzyme complex
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Plasma
- Serine protease
- Vitamin k