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Interleukin receptor antagonist

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Function

Interleukin-1 receptor antagonist (IL1RA) is a member of the interleukin-1 (IL1) cytokine family. IL1RA inhibits the activity of IL1, IL1A and IL1B. IL1RA modulates the activity of IL1-related immune and inflammatory responses. IL1RA binds to the IL1 receptor on the cell surface[1].

Relevance

IL1RA (or anakinra) is used as a drug in the treatment of rheumatoid arthritis[2].

Human interleukin-1 receptor antagonist dimer, 1ilr

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3D structures of IL1RA3D structures of IL1RA

2irt, 1ilr, 1ilt – hIL1RA – human
1irp - hIL1RA – NMR
1ira - hIL1RA + interleukin-1 receptor extracellular domain

ReferencesReferences

  1. ↑ Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998;16:27-55. PMID:9597123 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.27
  2. ↑ Mertens M, Singh JA. Anakinra for rheumatoid arthritis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD005121. doi:, 10.1002/14651858.CD005121.pub3. PMID:19160248 doi:http://dx.doi.org/10.1002/14651858.CD005121.pub3

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
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