1ujl

File:1ujl.gif

spinqualitylabelsall models PDB ID 1ujl Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Solution Structure of the HERG K+ channel S5-P extracellular linker

OverviewOverview

The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.

About this StructureAbout this Structure

1UJL is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

ReferenceReference

The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209

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