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5hde

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Crystal Structure of PTPN12 Catalytic DomainCrystal Structure of PTPN12 Catalytic Domain

Structural highlights

5hde is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Activity:Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PTN12_HUMAN] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.[1]

References

  1. ↑ Sahu SN, Nunez S, Bai G, Gupta A. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2288-96. Epub 2007 Feb 28. PMID:17329398 doi:http://dx.doi.org/10.1152/ajpcell.00503.2006

5hde, resolution 1.62Å

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