Proteopedia

Rho GTPase activating protein

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Function

Rho GTPase acivating protein (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions[1]. RhoGAPs contain a RhoGAP domain.

Relevance

RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy[2].

Structural highlights

Caption for this structure

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3D structures of Rho GTPase activating protein3D structures of Rho GTPase activating protein

4u3k - yRhoGAP 1 RhoGAP domain - yeast
5irc - RhoGAP 35 + transforming protein RhoA - rat
4rtt, 4rug - hRhoGAP 2 SLIT-ROBO residues 729-815 - human
2mio - hRhoGAP 10 SH3 domain - NMR
4wpc - yRhoGAP 1 F-BARR domain + inositol phosphate

ReferencesReferences

  1. ↑ Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003 Jan;13(1):13-22. PMID:12480336
  2. ↑ Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci. 2006 Aug;7(4):355-65. PMID:16918449

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky
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