Protein Nef

Function Protein Nef (Nef) or negative regulatory factor is an HIV and SIV accessory protein which establishes a persistent state of infection. Nef downmodulates the surface levels of molecules at the immune synapse. For more details see HIV and accessory proteins.

spinqualitylabelsall models HIV-I protein Nef (grey) complex with tyrosine protein kinase Hck SH3 domain (green) and ethanediol (PDB code 3rbb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of protein Nef3D Structures of protein Nef

Updated on 08-January-2017

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• Protein Nef
• 3tb8, 2xi1 – Nef – HIV-1
  
• 1qa5 – Nef anchor domain – NMR
  
• 1avv – Nef core domain
  
• 2nef – Nef core domain (mutant) – NMR
  
• Protein Nef complex
• 4u5w, 3rbb – Nef + tyrosine protein kinase Hck
  
• 3rea, 3reb – Nef (mutant) + tyrosine protein kinase Hck
  
• 4d8d, 1avz, 1efn – Nef + tyrosine protein kinase Fyn
  
• 4orz – Nef + tyrosine protein kinase Hck + single domain antibody
  
• 4nee – Nef + adapter-related protein complex 2 subunits σ, α-2
  
• 4emz, 4en2 – Nef + adapter-related protein complex 1 subunit μ-1 + MHC-I
  
• 3ik5, 3ioz – Nef + CD3 ζ - SIV