5gme

Crystal structure of Sulfolobus solfataricus Diphosphomevalonate decarboxylase in complex with ADPCrystal structure of Sulfolobus solfataricus Diphosphomevalonate decarboxylase in complex with ADP

Structural highlights

5gme is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Related:	5gmd
Activity:	Diphosphomevalonate decarboxylase, with EC number 4.1.1.33
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DMD_SULSO] Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.^[1]

References

↑ Nishimura H, Azami Y, Miyagawa M, Hashimoto C, Yoshimura T, Hemmi H. Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus. J Biochem. 2013 May;153(5):415-20. doi: 10.1093/jb/mvt006. Epub 2013 Feb 1. PMID:23378249 doi:http://dx.doi.org/10.1093/jb/mvt006

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OCA

[1] Nishimura H, Azami Y, Miyagawa M, Hashimoto C, Yoshimura T, Hemmi H. Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus. J Biochem. 2013 May;153(5):415-20. doi: 10.1093/jb/mvt006. Epub 2013 Feb 1. PMID:23378249 doi:http://dx.doi.org/10.1093/jb/mvt006

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