5fwc

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Human Spectrin SH3 domain D48G, E7A, K60AHuman Spectrin SH3 domain D48G, E7A, K60A

Structural highlights

5fwc is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[SPTN1_HUMAN] West syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[SPTN1_HUMAN] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

5fwc, resolution 1.40Å

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OCA