Nucleolin
FunctionNucleolin (NCL) is a multifunctional phosphoprotein found in the nucleolus, nucleus and cytoplasm. NCL contains intrinsic DNA and RNA helicase, nucleic-acid-dependent ATPase and self-cleaving activities. NCL binds RNA through its RNA recognition motifs (RBD). It regulates various aspects of DNA and RNA metabolism[1]. RelevanceNCL expression is enhanced on the surface of many different types of cancer cells and hence is the target of anti-cancer therapies[2]. NCL is a specific marker of angiogenic endothelial cells in tumor vessels[3]. Structural highlights |
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3D structures of nucleolin3D structures of nucleolin
Updated on 29-December-2016
2krr – hNCL RBD1-2 – human - NMR
2fc8, 2fc9 – hNCL RRM_1 domain - NMR
1rkj, 1fje – haNCL RBD1-2 + RNA – hamster - NMR
1fj7 – haNCL RBD1 - NMR
1fjc – haNCL RBD2 - NMR
ReferencesReferences
- ↑ Tajrishi MM, Tuteja R, Tuteja N. Nucleolin: The most abundant multifunctional phosphoprotein of nucleolus. Commun Integr Biol. 2011 May;4(3):267-75. doi: 10.4161/cib.4.3.14884. PMID:21980556 doi:http://dx.doi.org/10.4161/cib.4.3.14884
- ↑ Koutsioumpa M, Papadimitriou E. Cell surface nucleolin as a target for anti-cancer therapies. Recent Pat Anticancer Drug Discov. 2014 May;9(2):137-52. PMID:24251811
- ↑ Christian S, Pilch J, Akerman ME, Porkka K, Laakkonen P, Ruoslahti E. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J Cell Biol. 2003 Nov 24;163(4):871-8. PMID:14638862 doi:http://dx.doi.org/10.1083/jcb.200304132