Prolactin receptor

Function

Prolactin receptor (PRLR) mediates the prolactin hormone signal transduction cascade. Prolactin-dependent signaling occurs as a result of a ligand-induced dimerization of the PRLR^[1].

Relevance

The signaling action of PRLR/prolactin complex serve to control the pattern of gene expression that contributes to breast development and the pathobiology of breast cancer^[2].

Structural highlights

3D structures of prolactin receptor3D structures of prolactin receptor

Updated on 26-December-2016 3mzg, 3npz – hPRLR extracellular domain + hPRL - human
3d48, 3n06, 3n0p, 3ncb – hPRLR extracellular domain + hPRL (mutant)
3ncc, 3nce, 3ncf – hPRLR extracellular domain (mutant) + hPRL (mutant)
3ew3 – rPRLR extracellular domain + hPRL - rat
4i18 - hPRLR extracellular domain + antibody
2lfg - hPRLR extracellular domain d2 - NMR
1f6f – rPRLR extracellular domain + placental lactogen
1bp3 – hPRLR extracellular domain + growth hormone

ReferencesReferences

↑ Kline JB, Roehrs H, Clevenger CV. Functional characterization of the intermediate isoform of the human prolactin receptor. J Biol Chem. 1999 Dec 10;274(50):35461-8. PMID:10585417
↑ Clevenger CV. Role of prolactin/prolactin receptor signaling in human breast cancer. Breast Dis. 2003;18:75-86. PMID:15687690

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Kline JB, Roehrs H, Clevenger CV. Functional characterization of the intermediate isoform of the human prolactin receptor. J Biol Chem. 1999 Dec 10;274(50):35461-8. PMID:10585417

[2] Clevenger CV. Role of prolactin/prolactin receptor signaling in human breast cancer. Breast Dis. 2003;18:75-86. PMID:15687690

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