SAICAR synthetase

Function SAICAR synthetase (SAI) or phosphoribosylaminoimidazole-succinocarboxamide synthetase is part of the purine biosynthesis. SAI catalyzes ATP-dependent ligation of carboxyaminoimidazole ribotide (AICAR) with aspartate.

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3D structures of resolvase3D structures of resolvase

Updated on 26-December-2016

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• SAICAR synthetase
  • 1a48 – ySAI - yeast
    
  • 3r9r – SAI – Mycobacterium abscessus
    
  • 3kre – SAI – Ehrlichia chaffeensis
    
  • 1kut – SAI – Thermotoga maritima
    
• SAICAR synthetase complex
  • 2yzl – MjSAI + ADP – Methanocalcococcus jannaschii
    
  • 2z02 – MjSAI + ATP
    

**4fe2, 4nye – SpSAI + ADP + aspartate + AICAR – Streptococcus pneumoniae

• • 4fgr – SpSAI + ADP
    
  • 3nua – SAI + ADP + AMP – Clostridium perfringens
    
  • 2ywv – SAI + ADP – Geobsacillus kaustophilus
    
  • 2cnq – ySAI + ADP + AMP + succinate + AICAR
    
  • 2cnv – ySAI + aspartate + AICAR derivative
    
  • 2cnu – ySAI + aspartate
    
  • 1obd – ySAI + ATP + AMP
    
  • 1obg – ySAI + AMP
    
  • 2gqr – EcSAI + ADP – Escherichia coli
    
  • 2gqs – EcSAI + ADP + AICAR
    
• SAICAR synthetase type-1
  • 3u54 – PhSAI – Pyrococcus horikoshii
    
  • 4o81, 4o82, 4o83 – PhSAI + ADP + AMP
    
  • 4o84 – PhSAI + GMP
    
• SAICAR synthetase type-2
  • 3u55 – PhSAI
    
  • 4o7l, 4o7n – PhSAI + ADP
    
  • 4o7r – PhSAI + UMP + UDP
    
  • 4o7s – PhSAI + TMP + TDP
    
  • 4o7t – PhSAI + TMP + ADP + aspartate
    
  • 4o7v – PhSAI + UMP + UDP + ADP
    
  • 4o7w – PhSAI + ATP + TDP
    
  • 4o7y – PhSAI + CMP
    
  • 4o7z – PhSAI + GMP
    
  • 4o86 – PhSAI + ADP + CDP