Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein (VASP) belongs to the Ena-VASP family. It binds proteins with E/DFPPPPXD/E motif and targets them to focal adhesion cell membranes. VASP is associated with filament formation and promotes elongation.

VASP protects the actin barb edge against capping and increases the rate of actin polymerization in the presence of capping protein. VASP is a homotetramer. For more details see Group:MUZIC:Mena_VASP.

Human VASP (dark olive) complex with α-actin (grey), profilin-1 (green), ATP (stick model) and Ca+2 ion (green), 2pbd

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3D structure of vasodilator-stimulated phosphoprotein3D structure of vasodilator-stimulated phosphoprotein

Updated on 12-December-2016

1egx – hVASP EVH1 domain – human – NMR
1usd, 1use - hVASP tetramerization domain
2pav, 2pbd, 3chw – hVASP + actin + profilin-1

ReferencesReferences

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