Preprotein translocase

Function

Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor^[1]. The translocase pathway contains:

SecB - a chaperone protein^[2]
SecY, SecE, SecG an integral membrane complex
SecD, SecF - proteins promoting the release of the mature peptide into the periplasm
SecA - an ATPase unit^[3].

For more details see SecA PBD motions.

Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr)

Drag the structure with the mouse to rotate

3D structures of preprotein translocase3D structures of preprotein translocase

Updated on 20-November-2016

ReferencesReferences

↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663

[2] Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586

[3] Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931

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