Trichodiene synthase

Function

Trichodiene synthase (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene. TCS contains metal ion-binding motif^[1].

Structural highlights

Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) 2q9y

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3D Structures of trichodiene synthase3D Structures of trichodiene synthase

Updated on 22-September-2016

1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium

ReferencesReferences

↑ Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326

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