Thiol:disulfide interchange protein

Function Thiol:disulfide interchange protein (DsbC) is a prokaryotic disulfide bond isomerase. DsbC acts as a proofreader and breaks the incorrectly formed disulfide bonds. DsbC is activated by the N terminal domain of DsbD. DsbD transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state. DsbE catalyzes the reductive step in the assembly of periplasmic c-type cytochrome. DsbG provides reducing equivalents to rescue oxidatively-damaged secreted proteins. Structural highlights DsbC active site contains a CXXC motif which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space.

spinqualitylabelsall models E. coli DsbC complex with MES (PDB code 1eej) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of thiol:disulfide interchange protein3D Structures of thiol:disulfide interchange protein

Updated on 12-September-2016

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• Thiol:disulfide interchange protein (DsbC)
  • 1eej, 1tjd – EcDsbC – Escherichal coli
    
  • 1g0t, 1jzo – EcDsbC (mutant)
    
  • 2iyj – EcDsbC N terminal
    
  • 1jzd – EcDsbC (mutant) + DsbD N terminal
    
  • 1t3b – DsbC – Haemophilus influenzae
    
  • 4fyb, 4fyc – DsbC – Helicobacter pylori
    
  • 4i5q – StDsbC – Salmonella typhimurium
    
  • 4ilf – StDsbC (mutant)
    
• Thiol:disulfide interchange protein (DsbD)
  • 1l6p, 1jpe, 3pfu – EcDsbD N terminal
    
  • 1uc7, 2fwe, 2fwf 2fwg, 2fwh – EcDsbD C terminal
    
  • 4ip1, 4ip6 – EcDsbD C terminal (mutant)
    
  • 1vrs – EcDsbD N terminal (mutant) + C terminal (mutant)
    
  • 1z5y – EcDsbD N terminal (mutant) + EcDsbE soluble domain (mutant)
    
  • 2k0r – NmDsbD N terminal – Neisseria meningitis
    
  • 2k9f – NmDsbD N terminal + thoredoxin
    
• Thiol:disulfide interchange protein (DsbE)
  • 2b1k, 3k8n – EcDsbE
    
  • 2b1l, 2g0f – EcDsbE (mutant)
    
  • 3kh7, 3kh9 – DsbE soluble domain – Pseudomonas aeruginosa
    
• Thiol:disulfide interchange protein (DsbG)
  • 1v57, 1v58 – EcDsbG
    
  • 2h0g, 2h0h, 2h0i – EcDsbG (mutant)
    
  • 2iy2 – EcDsbG N terminal