5lsa

human catechol O-methyltransferase in complex with SAM and DNC at 1.50Ahuman catechol O-methyltransferase in complex with SAM and DNC at 1.50A

Structural highlights

5lsa is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Activity:	Catechol O-methyltransferase, with EC number 2.1.1.6
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[COMT_HUMAN] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

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OCA