Phosphocarrier protein

Function Phosphocarrier protein HPr (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated. Structural highlights The phosphorylation of Ser46 prohibits the HPr to act as a phosphocarrier in the EI reaction.

spinqualitylabelsall models Structure of phosphocarrier protein HPr (PDB entry 1fu0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of phosphocarrier protein HPr3D structures of phosphocarrier protein HPr

Updated on 08-September-2016

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• Phosphocarrier protein HPr
  • 2hpr - BsHPr (mutant) – Bacillus subtilis
    
  • 2hid - BsHPr (mutant) – NMR
    
  • 1jem - BsHPr (mutant) with phosphohistidine – NMR
    
  • 1sph – BsHPr
    
  • 1poh – EcHPr – Escherichia coli
    
  • 1opd, 1cm2, 1cm3, 3ccd - EcHPr (mutant)
    
  • 1hdn - EcHPr – NMR
    
  • 1pfh - EcHPr with phosphohistidine – NMR
    
  • 1ptf - EfHPr – Enterococcus faecalis
    
  • 1qfr - EfHPr – NMR
    
  • 1fu0 - EfHPr with phosphoserine
    
  • 1pch – HPr – Mycoplasma capricolum
    
  • 1qr5 - ScHPr – Staphylococcus carnosus - NMR
    
  • 1txe - ScHPr (mutant) – NMR
    
  • 1ka5 - HPr – Staphylococcus aureus - NMR
    
  • 1y4y – GsHPr – Geobacillus stearothermophilus
    
  • 1y50, 1y51 - GsHPr (mutant)
    
  • 3ihs – HPr – Bacillus anthracis
    
• Phosphocarrier protein HPr complex
  • 2jel - EcHPr + antibody
    
  • 3eze, 3ezb, 3eza - EcHPr + EI N terminal + PO3 – NMR
    
  • 2xdf - EcHPr + EI N terminal – NMR
    
  • 1ggr, 1j6t, 1vrc - EcHPr + EII N terminal + PO3 – NMR
    
  • 2lrk, 2lrl - EcHPr + EII N terminal – NMR
    
  • 1kkl - BsHPr (mutant) + HPrK
    
  • 1kkm - BsHPr (mutant) with phosphoserine + HPrK/P
    
  • 2fep - BsHPr with phosphoserine + BsCcpA
    
  • 1rzr – BmHPr with phosphoserine + BmCcpA + DNA - Bacillus megaterium
    
  • 2oen - BmHPr with phosphoserine + BmCcpA
    
  • 2nzu - BmHPr with phosphoserine + BmCcpA + glucose-6-phosphate
    
  • 2nzv - BmHPr with phosphoserine + BmCcpA + fructose-1,6-diphosphate
    
  • 3oqm, 3oqn, 3oqo - BsHPr with phosphoserine + BsCcpA + DNA