Spectrin

Spectrin forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.

3D Structures of Spectrin3D Structures of Spectrin

Updated on 30-August-2016

{"openlevels":0}

• Spectrin α1
  • 3lbx – hSPTA1+hSPTB1 – human
    
  • 3i9q, 2rot, 2pqh, 2oaw, 2nuz, 1u06 - cSPTA1 SH3 domain – chicken
    
  • 2jm8, 2jm9, 2cdt, 2f2v, 2f2w, 2f2x - cSPTA1 SH3 domain (mutant)
    
  • 2jma, 2jmc - cSPTA1 SH3 domain (mutant)+P41 peptide
    
  • 2rmo, 1neg, 1m8m - cSPTA1 SH3 domain – NMR
• Spectrin α2
  • 3f31 – hSPTA2 tetramerization domain
    
  • 1qkw – cSPTA2 SH3 domain (mutant)
    
  • 2fot - SPTA2+calmodulin – bovine
    
  • 3fb2 – hSPTA2 repeats 15-16
    
  • 3thk - SPTA2 SH3 domain + polypeptide - rat
• Spectrin α
  • 1uue, 1e7o, 1g2b, 1aey, 1tuc, 1tud - cSPTA SH3 domain (mutant) – NMR
    
  • 2lj3 - cSPTA SH3 domain – NMR
    
  • 1e6g, 1e6h, 1hd3, 1qkx, 1pwt, 1bk2, 1shg - cSPTA SH3 domain (mutant)
    
  • 1u4q – cSPTA repeats 15-17
    
  • 1u5p - cSPTA repeats 15-16
    
  • 1cun - cSPTA repeats 16-17
    
  • 1aj3 - cSPTA repeat 16 - NMR
    
  • 1owa - hSPTA tetramerization domain – NMR
    
  • 1h8k, 3ngp, 3m0p, 3m0q, 3m0r, 3m0s, 3m0t, 3m0u – cSPTA SH3 domain (mutant)
    
  • 2kr3, 4f17, 4f16 - cSPTA SH3 domain
    
• Spectrin β1
  • 3bkt, 3kbu - hSPTB1+ankyrin
    
  • 3f57, 3edu - hSPTB1 ankyrin binding domain
    
  • 1s35 – hSPTB1 repeats 8-9
• Spectrin β2
  • 3edv – hSPTB2 repeats 14-16
• Spectrin β3
  • 1wyq – hSPTB3 CH domain – NMR
    
  • 1wjm – hSPTB3 – NMR
• Spectrin β
  • 1bkr, 1aa2 – hSPTB CH domain
    
  • 1mph – SPTB Pleckstrin Homology domain – NMR
    
  • 1dro - mSPTB PH domain – NMR – mouse
    
  • 1btn – mSPTB+inositol phosphate
    
  • 2spc – SPT fragment - Drosophila melanogaster