Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domainsStructure of a 16 nm protein cage designed by fusing symmetric oligomeric domains

Structural highlights

3vdx is a 3 chain structure with sequence from Atcc 10762. The September 2013 RCSB PDB Molecule of the Month feature on Designed Protein Cages by David Goodsell is 10.2210/rcsb_pdb/mom_2013_9. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:bpoA2, BROMOPEROXIDASE A2, M, M1 Matrix (ATCC 10762)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BPOA2_STRAU] May be a chlorinating enzyme involved in 7-chlorotetracycline biosynthesis.

Publication Abstract from PubMed

Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials.

Structure of a 16-nm cage designed by using protein oligomers.,Lai YT, Cascio D, Yeates TO Science. 2012 Jun 1;336(6085):1129. PMID:22654051[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Lai YT, Cascio D, Yeates TO. Structure of a 16-nm cage designed by using protein oligomers. Science. 2012 Jun 1;336(6085):1129. PMID:22654051 doi:10.1126/science.1219351

3vdx, resolution 3.00Å

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