Structural highlights
3psn is a 2 chain structure with sequence from Lk3 transgenic mice. This structure supersedes the now removed PDB entry 3lh7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| Related: | 1w24, 1x2x, 1z2w, 2a22, 2r17, 3pso |
| Gene: | Vps29 (LK3 transgenic mice) |
| Activity: | Phosphoserine phosphatase, with EC number 3.1.3.3 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[VPS29_MOUSE] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro).