Proteopedia

Sandbox 130

Revision as of 21:27, 18 July 2016 by Allison Granberry (talk | contribs)

New Delhi Metallo-Beta-LactamaseNew Delhi Metallo-Beta-Lactamase

Insert caption here

Drag the structure with the mouse to rotate

Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Student, Meng Han Liu, Allison Granberry
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Sandbox_130&oldid=2618576"