User:Eric Martz/Protein 3D Structure Resources for Educators 2016

A Workshop for Educators at STCC
and other Springfield MA area colleges & schools.
by Eric Martz
Host: Dawn Tamarkin
1:00-5:00 PM, Monday and Tuesday, July 18 and 19, 2016
Springfield Technical Community College, 1 Armory Square, Springfield MA USA. Building 2, Room 614
Get here with STCC.MolviZ.Org

Lesson Plan with Assessment (3 afternoons)Lesson Plan with Assessment (3 afternoons)

		Enolase (4enl; an enzyme in glycolysis) evolutionary conservation from ConSurf. Catalytic pocket is highly conserved.

Introduction to Structural Bioinformatics 2016
Designed for undergraduate biological science majors (4 hours/afternoon x 3 afternoons = 12 lab hours)
Each student picks a different protein and does a report on how its structure supports its function
Sample Completed Report Section 9 is obsolete since animations can now be saved directly from FirstGlance

Tutorials on Specific MacromoleculesTutorials on Specific Macromolecules

In a computer lab, I like to hand out a short list of somewhat vague, open-ended questions to foster discussion in small groups of students. See Worksheets.
Most of these tutorials are in Proteopedia.Org, a wiki with user-authored content. Some articles are authored by students. As with Wikipedia, use your judgement. Unlike Wikipedia, authors' real names are at the bottom of each article and you can check their credentials by clicking on the names.

Molecules With Questions For Students (Java not needed)Molecules With Questions For Students (Java not needed)

DNA. Español (B form double helix) - A Nonlinear Tutorial / Discovery Tool
- Linear tutorial on DNA
Lac Repressor binding to DNA and bending the operon. Questions for Students.

Molecules With No Questions ... YetMolecules With No Questions ... Yet

No Java NeededNo Java Needed

Potassium channel (1R3J) showing membrane surface planes (click Jmol at OPM).

Anti-Alzheimer's drug analog (*) interaction with Acetylcholinesterase (1gpk, cf. 1vot).

Carbohydrates, lipids, vitamins, proteins, and nucleic acids. Español.
Myosin
Hemoglobin
Antibody
Ion Channels
Avian Influenza Neuraminidase, Tamiflu and Relenza
- Short animation: Molecular_Playground/Tamiflu
HIV-1 protease
- HIV Protease Inhibitor with simulation of binding with induced fit - ENLARGED for projection
Lipid Bilayers and the Gramicidin Channel
- Short version: Gramicidin Channel in Lipid Bilayer - Español
Collagen
Nucleosome structure
Ribosome

Water including liquid water and ice, and a simulation of hydrogen-bond formation.
SV40 Virus Capsid Simplified
Thermal motion of peptide, molecular dynamics simulation
Dramatic conformational change induced by calcium: Recoverin, a calcium-activated myristoyl switch

Tutorials requiring Java (fussy)Tutorials requiring Java (fussy)

Getting Java to work with the unsigned applets in these older tutorials is too fussy for most students, but these could be shown in lectures.

At MolviZ.Org: Hemoglobin, Antibody, Major Histocompatibility Complex. A different approach than the ones in Proteopedia.

Molecule of the MonthMolecule of the Month

These articles are authored by David S. Goodsell (The Scripps Research Institute and the RCSB PDB), a well-respected structural biologist.

Molecule of the Month has articles on many macromolecules, including
Molecules of the Month can be explored interactively, in more detail, by entering the 4-character PDB codes given near the end of each article into FirstGlance.Jmol.Org.

Make Your Own TutorialsMake Your Own Tutorials

Proteopedia.Org has Molecular Scene Authoring Tools that make it easy to create web pages with interactive macromolecules. Start at Help:Getting Started in Proteopedia and the Video Guides. Don't hesitate to ask for help from me!
Or you can add to any existing tutorial, or copy it and adapt it to your needs.

For ResearchersFor Researchers

A June 2016 workshop for researchers. Previous workshop syllabi at Workshops.MolviZ.Org.