Prostaglandin D synthase

Function Prostaglandin D synthase (PGDS) catalyzes the reversible conversion of 9α-11α-epidoxy-15-hydroxyprosta-5,13-dienoate to 9α-15-dihydroxy-11-oxoprosta-5,13-dienoate. Prostaglandin D2 synthase (PGD2S) catalyzes the conversion of prostaglandin H2 to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator in smooth muscle contraction. Human PGD2S has two isozymes: hematopoietic PGD2S found in mast cells see Glutathione S-transferase σ which is glutathione-dependent and lipocalin PGD2S found in the central nervous system, genital organs and heart. This enzyme is glutathione-independent and transports small hydrophobic molecules such as steroids. PGDS is a major constituent of cerebrospinal fluid. PGDS binds small lipophilic molecules like retinal and thyroid hormone. Hematopoietic PGDS is named also Glutathione S-transferase σ class. Glutathione is PGDS cofactor. Relevance PGDS is believed to be a cause of baldness.

spinqualitylabelsall models Human prostaglandin D synthase dimer complex with glutathione (PDB entry 2vcq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of prostaglandin D synthase3D structures of prostaglandin D synthase

Updated on 13-July-2016

Prostaglandin D2 synthaseProstaglandin D2 synthase

Lipocalin PGD2S (Glutathione-independent)

2e4j, 2rq0 - mPGD2S (mutant) – mouse – NMR
2ktd - mPGD2S (mutant) + substrate analog – NMR
2czt, 2czu – mPGD2S (mutant)
2wwp – hPGD2S - human
3o19, 3o22, 3o2y - hPGD2S (mutant) + oleate + palmitate

Hematopoietic PGD2S (Glutathione-dependent) see Glutathione S-transferase σ