Preprotein translocase

Function Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor. The translocase pathway contains: SecB - a chaperone protein SecY, SecE, SecG an integral membrane complex SecD, SecF - proteins promoting the release of the mature peptide into the periplasm SecA - an ATPase unit. For more details see SecA PBD motions.

spinqualitylabelsall models Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of preprotein translocase3D structures of preprotein translocase

Updated on 11-July-2016

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• Preprotein translocase SecY + SecE + SecB
  • 1rh5, 1rhz – MjPPT SecY + SecE + SecB – Methanocaldococcus jannaschii
    
• Preprotein translocase SecY + SecE + SecG
  • 2akh, 2aki – EcPPT SecY + SecE + SecG – Escherichia coli - CryoEM
    
  • 2yxq, 2yxr – MjPPT SecY + SecE + SecG
    
  • 3dkn – PPT SecY + SecE + SecG + RNA – dog - CryoEM
    
  • 3bo0, 3bo1 – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM
    
  • 3kcr, 3j45, 3j46 – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM
    
  • 1vvk – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM
    
• Preprotein translocase SecY + SecE
  • 3mp7 – PPT SecY + SecE – Pyrococcus furiosus
    
  • 2zjs – TtPPT SecY + SecE + antibody – Thermus thermophilus
    
  • 2zqp – TtPPT SecY + SecE
    
  • 3j01 – EcPPT SecY + SecE + large ribosomal subunit - CryoEM
    
• Preprotein translocase SecY + SecE + SecG + SecA
  • 3din – TmPPT SecY + SecE + SecG + SecA – Thermotoga maritima
    
  • 3dl8 – PPT SecY + SecE + SecA + SecG – Aquifex aeolicus - CryoEM
    
• Preprotein translocase SecA
  • 1m6n, 1tf5, 2ibm – BsPPT SecA – Bacillus subtilis
    
  • 3iqm, 3iqy – BsPPT SecA (mutant)
    
  • 1tm6 – EcPPT SecA C terminal - NMR
    
  • 2ipc – TtPPT SecA
    
  • 3jux – TmPPT SecA
    
  • 2fsf – EcPPT SecA
    
  • 2fsf – EcPPT SecA
    
  • 3bxz – EcPPT SecA dead motor domains (mutant)
    
  • 1nl3 – MtPPT SecA – Mycobacterium tuberculosis
    
• Preprotein translocase SecA complex
  • 1m74, 1tf2 – BsPPT SecA + Mg + ADP
    
  • 1ozb – PPT SecA C terminal + SecB - Haemophilus influenzae
    
  • 2fsh – EcPPT SecA + AMPPNP
    
  • 2fsi – EcPPT SecA + ADP
    
  • 2fsg – EcPPT SecA + ATP
    
  • 2vda – EcPPT SecA + maltoporin signal peptide - NMR
    
  • 3jv2 – BsPPT SecA + peptide
    
  • 1nkt – MtPPT SecA + ADP