Template:STRUCTURE 3ig3
Plexin (PLX) is the receptor for semaphorin[1].
- Plexin A controls axon guidance[2].
- Plexin B regulates Rho GTPase[3].
3D structures of plexin3D structures of plexin
05-July-2016
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- Plexin A
- 3al8, 3oky – mPLX-A2 + semaphorin-6A – mouse
- 4gza - mPLX-A2 + semaphorin-3A + neuropilin-1
- 3al9, 3okt – mPLX-A2 extracellular domain
- 3ig3 - mPLX-A3 intracellular domain
- 3ryt - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate
- 3q3j - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human
- 4e74 - hPLX-A4 Rho GTPase-binding domain
- Plexin B
- 2r2o – hPLX-B1 effector domain
- 2rex - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
- 2jph - hPLX-B1 Rho GTPase-binding domain – NMR
- 4e71 - hPLX-B2 Rho GTPase-binding domain
- 3ol2 - hPLX-B1 + semaphorin 4D
- 3sua, 3su8 – hPLX-B1 + RAS-related C3 botulinum toxin substrate
- 3hm6 - hPLX-B1 cytoplasmic domain + peptide
- Plexin C
- 3kuz - hPLX-C1 ubiquitin-like domain
- 3nvn, 3nvq – hPLX-C1 + semaphorin 7A
- Plexin D
- 3h6n - hPLX-D1 ubiquitin-like domain
ReferencesReferences
- ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
- ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
- ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200