Phosphocarrier protein

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Phosphocarrier protein HPr (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr[1]. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated.

Structure of phosphocarrier protein HPr (PDB entry 1fu0)

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3D structures of phosphocarrier protein HPr3D structures of phosphocarrier protein HPr

Updated on 23-June-2016

ReferencesReferences

  1. Postma PW, Lengeler JW, Jacobson GR. Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria. Microbiol Rev. 1993 Sep;57(3):543-94. PMID:8246840

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman