Nuclear transcription factor Y

Function

Nuclear transcription factor Y (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence^[1]. See details in NF-Y Transcription Factor.

Relevance

NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer^[2].

Structural highlights

The interaction of NFY with the promoter CCAAT sequence, involves an insertion of an NFY helix into the minor groove of the DNA^[3].

Human nuclear transcription factor Y subunit α (cyan), subunit β (green) and subunit γ (deeppink) complex with HSP70 promoter fragment (PDB code 4awl)

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3D Structures of nuclear transcription factor Y3D Structures of nuclear transcription factor Y

Updated on 16-May-2016

1n1j, 4csr – hNFY β+γ subunits - human
4awl – hNFY α+β+γ subunits + promoter DNA

ReferencesReferences

↑ Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081
↑ Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180
↑ Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R. Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination. Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047. PMID:23332751 doi:http://dx.doi.org/10.1016/j.cell.2012.11.047

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081

[2] Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180

[3] Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R. Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination. Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047. PMID:23332751 doi:http://dx.doi.org/10.1016/j.cell.2012.11.047

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