Neuroligin

Crystal Structure of human Neuroligin 3be8

FunctionFunction

Neuroligins (NLGN) are a family of postsynaptic proteins which bind to the presynaptic Neurexin (NRXN) to form a complex which attaches neurons. In humans the NLGN family contains 4 to 5 members that are numbered 1, 2, 3, 4X and 5 or 4Y^[1].

See Neurodevelopmental Disorders

Neuroligin-Neurexin Interaction

NLGN-1 regulates spines and synaptic plasticity^[2].
NLGN-2 is localized to inhibitory synapses^[3].
NLGN-4 is localized to glyceric post-synapses and regulates retina inhibition^[4].

DiseaseDisease

Mutations in NLGN 4 are associated with autism and mental retardation^[5].

3D Structures of Neuroligin3D Structures of Neuroligin

10-May-2016

ReferencesReferences

↑ Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P. Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521 doi:10.1016/j.neuron.2007.11.013
↑ Koektuerk B, Turan CH, Yorgun H, Keskin K, Schoett M, Dahmen A, Gorr E, Yang A, Hoppe C, Horlitz M, Turan RG. The total incidence of complications and the impact of an anticoagulation regime on adverse events after cryoballoon ablation of atrial fibrillation: A single center study of 409 patients. Cardiovasc Ther. 2016 Feb 16. doi: 10.1111/1755-5922.12178. PMID:26880220 doi:http://dx.doi.org/10.1111/1755-5922.12178
↑ Varoqueaux F, Jamain S, Brose N. Neuroligin 2 is exclusively localized to inhibitory synapses. Eur J Cell Biol. 2004 Sep;83(9):449-56. PMID:15540461 doi:http://dx.doi.org/10.1078/0171-9335-00410
↑ Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoe-Pognetto M, Lowel S, Moser T, Taschenberger H, Brose N, Varoqueaux F. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3053-8. doi:, 10.1073/pnas.1006946108. Epub 2011 Jan 31. PMID:21282647 doi:http://dx.doi.org/10.1073/pnas.1006946108
↑ Zhang C, Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Sudhof TC. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci. 2009 Sep 2;29(35):10843-54. doi: 10.1523/JNEUROSCI.1248-09.2009. PMID:19726642 doi:http://dx.doi.org/10.1523/JNEUROSCI.1248-09.2009

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, David Canner, Michal Harel, Pascale Marchot, Joel L. Sussman

[1] Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P. Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521 doi:10.1016/j.neuron.2007.11.013

[2] Koektuerk B, Turan CH, Yorgun H, Keskin K, Schoett M, Dahmen A, Gorr E, Yang A, Hoppe C, Horlitz M, Turan RG. The total incidence of complications and the impact of an anticoagulation regime on adverse events after cryoballoon ablation of atrial fibrillation: A single center study of 409 patients. Cardiovasc Ther. 2016 Feb 16. doi: 10.1111/1755-5922.12178. PMID:26880220 doi:http://dx.doi.org/10.1111/1755-5922.12178

[3] Varoqueaux F, Jamain S, Brose N. Neuroligin 2 is exclusively localized to inhibitory synapses. Eur J Cell Biol. 2004 Sep;83(9):449-56. PMID:15540461 doi:http://dx.doi.org/10.1078/0171-9335-00410

[4] Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoe-Pognetto M, Lowel S, Moser T, Taschenberger H, Brose N, Varoqueaux F. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3053-8. doi:, 10.1073/pnas.1006946108. Epub 2011 Jan 31. PMID:21282647 doi:http://dx.doi.org/10.1073/pnas.1006946108

[5] Zhang C, Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Sudhof TC. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci. 2009 Sep 2;29(35):10843-54. doi: 10.1523/JNEUROSCI.1248-09.2009. PMID:19726642 doi:http://dx.doi.org/10.1523/JNEUROSCI.1248-09.2009

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