Metabotropic glutamate receptor

spinqualitylabelsall models Structure of the binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate and gadolinium ions (1isr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Metabotropic glutamate receptors are glutamate receptors that activate ion channels indirectly through a signaling cascade involving G proteins. They are members of the large class of seven-transmembrane domain receptors, the G protein-coupled receptors. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also Ligand Binding N-Terminal of Metabotropic Glutamate Receptors.

• Metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 belong to group I and activate phospholipase C.
  
• Metabotropic glutamate receptor 2 and metabotropic glutamate receptor 3 belong to group II and inhibit the cyclic AMP cascade.
  
• Metabotropic glutamate receptor 7 belongs to group III and inhibits adenylate cyclase activity.
  

Articles in Proteopedia concerning Toll-like Receptors include:

• Leucine-rich repeat
• Membrane proteins

3D structures of metabotropic glutamate receptor3D structures of metabotropic glutamate receptor

Updated on 21-April-2016

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• Metabotropic glutamate receptor 1
  • 1ewt, 1ewv - rMGluR1 LBD - rat
    
  • 3ks9 – hMGluR1 (mutant) + antagonist - human
    
  • 4or2 - hMGluR1/cytochrome b526
    
  • 1isr, 1ewk – rMGluR1 LBD + Glu
    
  • 1iss - rMGluR1 LBD + antagonist
    
• Metabotropic glutamate receptor 2
  • 4xas, 4xaq – hMGluR2 LBD + agonist
    
• Metabotropic glutamate receptor 3
  • 2e4u – rMGluR3 LBD (mutant) + Glu
    
  • 2e4v, 2e4w, 2e4x, 2e4y, 2e4z - rMGluR3 LBD (mutant) + agonist
    
  • 3sm9 - hMGluR3 + antagonist
    
  • 4xar – hMGluR3 LBD + agonist
    
• Metabotropic glutamate receptor 5
  • 3lmk – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu
    
• Metabotropic glutamate receptor 7
  • 3mq4 – hMGluR7 LBD + antagonist
    

See AlsoSee Also

Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease